Precision Medicine will need to get out of the pharma silo that is based on symptoms


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an
early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs?

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Precision Medicine in Organ Transplant

Jesus CRISPR Super Star





Scientists from Australia & UK have created a “biosensor mouse” that predicts spread of pancreatic cancer cells https://t.co/SxgnGBSh7O
If dying Steve Jobs
And Andrew Lloyd Webber
Wrote a Musicome
"Aren't you tired of all those
revivals?"
It would tell the story
Of that cool genome
editing tool:
CRISPr.
Who is this Jesus CRISPr?
The superstar
Helping parents
With a sick son
Get a Nobel Prize.

"Cracking the Code"
"Fixing the Code"
All done by parents:
The Mission Massimo team.

Nobody else seems
to be in charge.
Not even doctors
Not even scientists
Not even academia
Not even big pharma.

Many thought
Mission Massimo was crazy.
But at M.I.T.
I was told that
"Crazy" could earn you a Nobel Prize
Even if you have no PhD
But end up
Changing medicine.

Jesus CRISPr and Mission Massimo
Did some disease modeling on a mouse
Then they built a platform
To cure thousands of people.

Three decades later
Old Mission Massimo
Steals the show.
Jesus CRISPr Superstar
Sharing a Nobel Prize
With the crazy people.



















 Patients Just Care About A Cure


The Very Private Life of My Genome

Welcome to this stupid blog I started in 2005.

This is me. Still struggling to find some kind of comfort zone. Any comfort zone would do, I am neither picky nor fussy... But I can't seem to get there, as I keep falling into those bloody holes... Meanwhile, time is ticking...

https://fr.pinterest.com/source/strangeling.com
My husband, Eric, is a mixture of the Grinning Cat and R2y (R2D2).

Should I start looking for my ancestors and my genetic profile?
23andMe, what do you make of this??...
http://alecx8.deviantart.com/art/Spock-to-the-Hand-On-Sale-379447391

Follow me on Weibo


CRISPR Side Story


"The Patient Will See You Now" French Version

http://tinyurl.com/mawk4vf





Best Book Of The Month Nonfiction (Amazon): "The Patient Will See You Now". Looks like health care needs a massive reboot...


"It's not about looking something up on the internet. It's about your own data, real time."

Eric Topol MD, Cardiologist: "Patients can now have their own cardiogram on their iPhone."
Putting patients in charge of their own data, instead of Doctors?
Putting patients in charge of their data instead of Doctors? Sounds like a printing press revolution.
"It's not about looking something up on the internet. It's about your own data, real time."
Healthcare revolution will comme from outside of healthcare.
The Future of Medicine? Doctors will still be needed.


Biology and IT have merged. Time to learn about it



Airpocalypse Now

Yay, I can access this old crappy blog of mine from Beijing!
http://www.iflscience.com/environment/snow-sponge-toxic-car-exhaust-particles

At Beijing airport, Jan. 15, 2016 (sorry, not good at taking selfies. Not sure I want to "selfie" myself again...)
Totally loved MIT Tech Review's sci-fi "Twelve Tomorrows"


Trying to write a dystopian fiction about mHealth in China (which explains why I am in Beijing right now...)

"My Health Upgraded" by Berci Mesko MD

Opening of Berci's book: "My Health Upgraded"


Reading Berci's book, preparing my review on Amazon...

Genomics Festival London






"Immaculate suppression"


The IBM and Linux of Genomics





Nerd Royalty: Long Live The Telomere!


https://med.stanford.edu/news/all-news/2015/01/telomere-extension-turns-back-aging-clock-in-cultured-cells.html

"Nerd Royalty"


Eric Topol MD's 2.0 version is Hero 6's Baymax

"Medical Blockbuster of the Year" (Forbes):


This book already exists as a fiction, by the way... So the 2.0 version of Eric Topol MD would be... Baymax. Healthcare artist and activist Regina Holliday will love this! Baymax Will See You Now.


"On a scale from 1 to 10..."
"My hands are equipped with defibrillators...Clear."
Actually, Baymax could be quite helpful in "genomic" precision medicine... Who will build him? The IBM of health care or some MIT students, in some kind of open-source mode? Intellectual Property and Digital Rights Management are building tomorrow's empires... San Franciskyoto Side Story...

A Risky Business

Seeing ghosts? Some have tried to turn this curse into something useful...


But still, it's a risky business...
Wait. Why not try to turn this curse into... a business?...

No, I don't mean (dead) Bruce Willis helping a (cursed) little boy...


Why not try working with doctors and surgeons? If they are using outdated science, the "cursed" person working with them might see ghosts -- the dead victims of outdated science. Turning the curse/gift into some cool detector of outdated science... Organ transplant medicine could be a great place to start. Scientific polemics around "brain death", organ trafficking worldwide, shortage of organ "donation", surgeons under pressure...

Then the unexpected can happen, like some unfortunate cursed woman meeting with a gorgeous "brain-dead" ghost (not so brain-dead, actually. He was a brilliant mathematician)... Hey, that poor woman may be cursed and miserable and not so good at handling rejection, but at least she gets to choose her Bruce Willis, right?

http://opinionator.blogs.nytimes.com/2016/01/06/my-marriage-didnt-end-when-i-became-a-widow

Now this is something entirely different... The death of a young brain surgeon, his widow trying to find some rest on his grave, as she is in too much pain to be able to sleep... Would you say this woman is seeing a ghost? I don't think so. Seeing a ghost means you've never met this person before (which is aggravating the situation. Yup,there's a reason it's called a curse).

Burton's "Corpse Bride"

Maybe some (dead) victims of outdated science and (dead) young and brilliant scientists will somehow meet and work together on some "mad science" project? I'm curious as to the outcome of this, especially in the context of high-speed internet ghosts and a new emerging religion... Jesus-CRISPR superstar...

I told you. It's a risky business. But isn't the goal of science to remind us that no fate is destined to inevitably befall us (entropy, disease, rejection, unemployment)?

Science is averting fatalities...


Enjoying the creative process of fiction writing


"Brief Candle In The Dark"


Human-Animal Chimeras?


"By modifying genes, scientists can now easily change the DNA in pig or sheep embryos so that they are genetically incapable of forming a specific tissue. Then, by adding stem cells from a person, they hope the human cells will take over the job of forming the missing organ." (Reddit)

"The Waiting Room"













Girl & gulls