Precision Medicine will need to get out of the pharma silo that is based on symptoms
Welcome to the digital era of biology (and to this modest blog I started in early 2005).
To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!
Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.
After low-cost airlines (Ryanair, Easyjet ...) comes "low-cost" participatory medicine. Some of my readers have recently christened this long-lasting, clumsy attempt at e-writing of mine "THE LOW-COSTE INNOVATION BLOG". I am an early adopter of scientific MOOCs. My name's Catherine Coste. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.
Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).
I love Genomics. Would you rather donate your data, or... your vital organs?
Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.
Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).
.@leahkam @missionmassimo Eric Lander says as long as we don't have a learning #healthcare syst -> #silo @NatalieShau pic.twitter.com/clHTmD2QRG— CATHERINE COSTE (@cathcoste) August 28, 2015
|Copyright: Natalie Shau.|
We don't have a learning healthcare syst. says @eric_lander -> @raredisease patients are on their own & Doctors are on Life Support #PWSYN— CATHERINE COSTE (@cathcoste) August 28, 2015
#biotech @jdudley @konradjk @vsbuffalo @missionmassimo @leahkam @SystemsSally @krening @OReillyMedia @ninatandon TY. pic.twitter.com/Aup1AYoWwB— CATHERINE COSTE (@cathcoste) August 28, 2015
First, the Human Genome Project with @eric_lander. Then, the Human Diagnosome Project with @missionmassimo @leahkam. pic.twitter.com/6q9uiRVzKH— CATHERINE COSTE (@cathcoste) September 9, 2015
#cellhaiku by Catherine Coste, inspired by Nina Tandon.
I am an IT & Cell Architect
Circuitry of human cells
I am a maker
With a biocomputer.
Chip on your shoulder?
Put it in a cell. Human on chip.
Yesterday I grew
Snippets of code
From my RNA.
When I grow old
Snippets of organs
From my DNA.
« I want you to engineer a molecule. »
My body cells
Snippets of bugs,
Code on fire, hug & mug:
Snug bucket list
Scripting in Java
C++ Signature Claws
Of Schrödinger’s cat
Speaking snake language
Replicating inThe Social Network.
.@randomhouse @leahkam @missionmassimo My Amazon review of #CrackingTheCode http://t.co/ejjp5JQbiV #PWSYN @FLGenomics pic.twitter.com/cfsmSSeEya— CATHERINE COSTE (@cathcoste) August 24, 2015
|Already a bestseller in Australia!|
|Cracking The Code|
.@SwissGator @ManeeshJuneja @healthbankcoop @leonardkish @mjseres parents pushing the envelope = market makers #DNA pic.twitter.com/VvFYhTavcC— CATHERINE COSTE (@cathcoste) August 24, 2015
.@leahkam Doctors usually don't write a bestseller about patients they don't understand or with complications. They shield themselves #PWSYN— CATHERINE COSTE (@cathcoste) August 25, 2015
.@didierfesquet @SOLVE_MIT French Bioethics Laws forbid citizens to request their genome sequencing on their own initiative (fine, prison).— CATHERINE COSTE (@cathcoste) August 22, 2015
Illustrating @JCVenter: My greatest fear is not the abuse of technology but that we will not use it at all @SOLVE_MIT pic.twitter.com/hUEBAy8TO7— CATHERINE COSTE (@cathcoste) August 22, 2015
Cracking The Code; then: Fixing The Code. Stay tuned.Pioneers. May The Force Be With You #StarWars http://t.co/Jy3bf2YZV7 @leahkam @missionmassimo #entertainment #PWSYN pic.twitter.com/S021qX5Jst— CATHERINE COSTE (@cathcoste) August 22, 2015
|"Cracking The Code" is already a bestseller in Australia. This book has been published by Randome House Books|
No better place to start exploring your genome (even for lay individuals) than this book, says @geochurch #PWSYN #DNA pic.twitter.com/c50c5OLfGm— CATHERINE COSTE (@cathcoste) August 20, 2015
Cracking the #DNA Code Market @my_helix http://t.co/DkVlEMAMjY by @antonioregalado @techreview #PWSYN @missionmassimo pic.twitter.com/7qP98EHg4x— CATHERINE COSTE (@cathcoste) August 20, 2015
Owning You Medical Data Is The True Freedom #Dune #SciFi #DTCgenomics #genomics #PrecisionMedicine @portablegenomic pic.twitter.com/y5czzcVgrH— CATHERINE COSTE (@cathcoste) August 20, 2015
.@cathcoste @portablegenomic They sequence 4 free, @healthbankcoop store 4 free if u the righful data owner agree to particapte in research— Mark Hummel (@MarkHummel3) August 20, 2015
.@MarkHummel3 @portablegenomic @healthbankcoop I want to have my genome sequenced for free & make it available for research purposes #PWSYN— CATHERINE COSTE (@cathcoste) August 20, 2015
And my business model would be: ownership of medical data by the patient:
And my business model would be: ownership of medical data by the patient. https://t.co/qr3QvcEnhp— CATHERINE COSTE (@cathcoste) August 21, 2015
What To Expect From Sequencing Your Microbiome? - The Medical Futurist https://t.co/HoWte3fKNx #digitalhealth #microbiome @ubiome— Berci Meskó, MD, PhD (@Berci) August 17, 2015
.@Berci got his gut (gastrointestinal tract) #microbiome sequenced @uBiome @jessicarichman + what it told him https://t.co/VpXACP6ITR #PWSYN— CATHERINE COSTE (@cathcoste) August 18, 2015
Data hoarding. No sharing. Big Pharma looking for blockbusters only. And then, this:
.@dgmacarthur: The current academic publication system does patients a huge disservice http://t.co/vEl1evSY9x #PWSYN pic.twitter.com/naWdaxdHxK— CATHERINE COSTE (@cathcoste) August 18, 2015
Predicting Organ Transplant Rejection and other things a liquid biopsy can do, by Antonio Regalado (MIT)
This outstanding webinar just took place. If you want to know if whole exome (WES) or whole genome (WGS) should be sequenced (and which is best), and if healthy people should also get their genome sequenced, and gain insight into patients' stories (how genomics could help them)... look no further. Dr. Elizabeth Worthey talked about children who had their genome sequenced either on time (and it helped find a cure for them) or too late (heartbreaking stories, you've been warned)...@cathcoste @PersonalizedMed @TheScientistLLC Shameless plug. Want to change how we practice medicine. Join my team: https://t.co/4jOHaNWrpW— liz worthey (@lizworthey) August 14, 2015
.@PersonalizedMed @TheScientistLLC @lizworthey Thank you for this great webinar #precisionmedicine cc @missionmassimo pic.twitter.com/HhK19fquhl— CATHERINE COSTE (@cathcoste) August 13, 2015
Dept. of Pigoons: Surgeons Smash Records with Pig-to-Primate Organ Transplants http://t.co/GZ3mP8XG40— Antonio Regalado (@antonioregalado) August 12, 2015
“We want to make organs come off the assembly line, a dozen per day.” http://t.co/9c3Ez3gFc2— Brian Bergstein (@BrianBergstein) August 12, 2015
Math, Medicine & Motorcycles http://t.co/u41AHWfijg My fun interview w/the brilliant daredevil Eric Schadt @Medscape pic.twitter.com/mCBp8oPYrL— Eric Topol (@EricTopol) August 11, 2015
In @FLGenomics Mag., I wrote about #healthcare being disrupted by Moore's Law #PWSYN @MITxBio http://t.co/23LgeQkS3A pic.twitter.com/XqT7zT3jHj— CATHERINE COSTE (@cathcoste) August 10, 2015
— MCCIM (@MayoClinicCIM) August 4, 2015
.@FLGenomics has great interview with @JCVenter, keynote speaker at #CIMCon15. Plus check out @cathcoste Kinky MOOCs. http://t.co/l1ruExc9yZ
I'm just a #MOOC student. It's been a pleasure to write in such good company ;) TY @FLGenomics http://t.co/rFc2L98Nas pic.twitter.com/KfwrV5xWiU— CATHERINE COSTE (@cathcoste) August 4, 2015